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The Greatest Canadian Invention: Insulin

Posted by Ian / January 12, 2007

insulin_20071012.jpg

In slightly-old news, the CBC aired a program last week announcing the Greatest Canadian Invention: the Toronto-created insulin. Other notable Toronto inclusions are the electron microscope, the G-suit, the light bulb (with the patent sold to Edison, somehow a very Toronto thing to do), pablum, and UV degradable plastics. The somewhat random list is still up on the CBC's website, although if there's one selection that isn't debatable it's poutine. I think I would have put it ahead of five-pin bowling, at least. If we had to come up with a list of the Greatest Torontonian inventions, what would top it? I'd nominate the Peameal Bacon Sandwich, but I'm sure we've birthed greater contributions to the city and the world at large. Feel free to drop ideas into the comments section if you think of anything worthy of the honour.

Image from the CBC.

Discussion

15 Comments

Jerrold / January 12, 2007 at 01:10 pm
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I work with electron microscopes, and my grandmother takes insulin daily. Toronto certainly has done some great things for medicine and science discovery.
Deea / November 13, 2007 at 09:26 pm
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I think you are crazy , the insuline was invented by a roumanian: Nicolae Paulescu (October 30, 1869-July 17, 1931) was a Romanian physiologist, professor of medicine and the discoverer of insulin.
Eight months after Paulescu's works were published, doctor Frederick Grant Banting and biochemist John James Richard Macleod from the University of Toronto, Canada, published their paper on the successful use of a pacreatic extract for normalizing blood sugar (glucose) levels (glycemia) in diabetic dogs. Their paper is a mere confirmatory paper, with direct references to Paulescu's article. However, they misquote that article, enunciating that:

"He [Paulescu] states that injections into peripheral veins produce no effect and his experiments show that second injections do not produce such marked effect as the first",

which is exactly the opposite of what Paulescu found out. Later on, Banting said that

"I regret very much that there was an error in our translation of Professor Paulescu's article, I cannot recollect, after this length of time, exactly what happened (...) I do not remember whether we relied on our own poor French or whether we had a translation made. In any case I would like to state how sorry I am for this unfortunate error (...)"

Surprisingly, Banting and Macleod received the 1923 Nobel Prize in Physiology or Medicine for the discovery of insulin, while Paulescu's pioneering work was being completely ignored by the scientific and medical community. International recognition for Paulescu's merits as the true discoverer of insulin came only 50 years later.

Professor Ian Murray, an internationally regarded physiologist, was particularly active in working to correct the historical wrong against Paulescu. Murray was a professor of physiology at the Anderson College of Medicine in Glasgow, Scotland, the head of the department of Metabolic Diseases at a leading Glasgow hospital, vice-president of the British Association of Diabetes, and a founding member of the International Diabetes Federation. In an article for a 1971 issue of the Journal of the History of Medicine and Allied Sciences, Murray wrote:

"Insufficient recognition has been given to Paulesco, the distinguished Roumanian scientist, who at the time when the Toronto team were commencing their research had already succeeded in extracting the antidiabetic hormone of the pancreas and proving its efficacy in reducing the hyperglycaemia in diabetic dogs."

Furthermore, Murray reported:

"In a recent private communication Professor Tiselius, head of the Nobel Institute, has expressed his personal opinion that Paulesco was equally worthy of the award in 1923."

Razvab / November 5, 2008 at 11:47 pm
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Its all romania.
bobo / January 15, 2009 at 01:42 pm
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What the fuck?
random / February 12, 2009 at 11:15 am
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That is all false.
everyone is just trying to take Canada history
adi85 replying to a comment from random / September 5, 2009 at 11:22 am
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It is true. Paulescu failed to continue his studies due to financial problems so the merits of Banting and Macloed are those of giving the international comunity knoledge of the discovery of insulin. However claiming that it was their discovery is plagiarism. More , they renamed it insulin although Paulescu already pateneded it pancrein(e)in Romania. The nobel committee were most likely aware of this but Paulescu was known for his antisemitic and antimasonic views...
DooDoo replying to a comment from bobo / December 7, 2009 at 09:46 pm
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Look man, chill out. No need to pul out insulting words...
bob / March 15, 2010 at 09:55 am
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Ok then, do you have any other proofs other than yourself that Dr. Federick Banting didn't discover insulin?
accidutzzu / March 16, 2010 at 09:26 pm
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Well yes he has - Paulescu did discover it 4 years before Banting and published his experiments at the time.
I think both should have claimed the prize at the time - given the fact Paulescu discovered it and Banting had tried it in clinical trials. Anyway it was not the first time a discovery was given only to another party in history ...
turtles145 / April 22, 2010 at 11:48 am
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canadians have allways done great things in history. i have read all theis comments and both sides make good points but who gives a shit that guys grandpa is alive of what people did. they both wanted to save lives, they werent affter the money or the prize get over it things happen and yes it is trew that paulescu discovered it first but banting did the tests so....... yeah the both did there part in history ok. listen to accidutzzu hes asying the same thing i am gtg
lovely / September 16, 2010 at 10:31 am
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the same thing happened with the lightbulb, Thomas edison didn't invent it but merely improved it because the Canadian inventer, Henry Woodward didn't have the finances. But Thomas Edison has received world wide recognition for the light bulb. So I'm pretty sure this happens A LOT in history
gigo / October 18, 2010 at 09:11 pm
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weird
Aly / April 2, 2011 at 09:25 pm
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Here you are wrong, the insulin what invented by a Romanian named Nicolae Paulescu. I'm sorry for you if you aren't very informed, but i see that here is a filter of information for the people on the west side so they aren't completely informed about avaerything.
hi dumb people / June 9, 2011 at 05:43 pm
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you arre all fucking dumb. it was frederick banting.
Just / July 23, 2011 at 12:38 am
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The first person who invented insulin was a Romanian scientist named Nicolae Paulescu in the year 1916
The Romanian scientist who invented insulin saw a problem and solved it when no-one else could. Nicolae succeeded in creating an aqueous pancreatic extract proved to have an effect on the blood sugar levels of a person suffering from diabetes. During the time of April 24 to June 23 1921, Nicolae had published four articles at the Romanian Section of the Society of Biology in Paris, all of which were describing different factors involving the effects of the new drug he created pancreine. Eight months after Nicolae published his work, Banting and Macleod from the University Of Toronto, Canada, published their own papers on the success of pancreatic extracts for the normalizing of blood sugar levels. While Nicolae had patented has technique in his home country, there was no clinical use resulting from his work. However, the work that was published by Banting and Macleod represented the injection of insulin into a diabetic person ameliorating the symptoms of the disease where the results were satisfying.

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